A study funded by the US National Institutes of Health examines the possibility of vaccine “mixing”, that is, using a different vaccine with a booster dose than previous doses. Currently, such treatments are not permitted in the United States.
The study was conducted on 458 adults who were vaccinated with one of three preparations approved in the United States (Pfizer, Moderna, or Johnson & Johnson). Each of the three groups was divided into three new groups in order to once again receive one of the three vaccines available as a booster.
The researchers then analyzed antibody levels 15 days after the booster injection. He found that in first-timers vaccinated with the Johnson & Johnson vaccine, antibody levels increased 4-fold after a booster dose of the same vaccine, 35-fold with a booster dose of Pfizer and 76-fold after a booster dose of Moderna.
In contrast, those first vaccinated with Moderna had higher antibody levels each time compared to those first vaccinated with Pfizer or Johnson & Johnson, regardless of the booster vaccine.
Earlier on Wednesday, the Food and Drug Administration (FDA) announced that Moderna’s Covid-19 vaccine does not meet all criteria that warrant approval for its third dose. An extra dose of Moderna’s vaccine has been found to increase antibody levels, but this difference isn’t very clear, especially for people whose antibody levels remained elevated.
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