Drink coffee, and you will get healthy muscles.  An interesting discovery for scientists

An international research consortium has discovered this A natural compound found, among other things, in coffee that can be useful in improving the health and function of muscles. Previous research on this plant alkaloid, trigonelin, has also shown its other positive properties for human health.

The new analyzes were based on previous research on muscular dystrophy, a condition characterized by the loss of skeletal muscle mass and function. The disease mainly affects the elderly, but not only – it is also associated with obesity, for example. In the new work, scientists focused on compounds that affect the proper functioning of muscles. Trigonelin, already known to researchers for its other health-promoting properties, which occurs naturally, among others, in coffee and fenugreek, has also been discovered to have a significant effect on supporting muscle tissue.

The important point is that it is bound to NAD+, a coenzyme that occurs naturally in the body – a major component of cells. The discovery of NAD+, a derivative of vitamin B3, was a breakthrough in the search for the secret of longevity due to its “rejuvenating” properties. Now experts have analyzed its links with trigonelline.

“The functions of trigonelin in cellular metabolism and its applications for muscle health during aging open promising new possibilities,” said Jerome Vige, Head of Physical Health at Nestlé Research.

Trigonelline has been known to researchers for a long time. The plant alkaloid occurs, among others, in: coffee, fenugreek and radish. It is already known to improve cognitive abilities, including memory, and is also useful in inhibiting inflammatory processes in the nervous system. Now more discoveries have been made about its properties.

Our findings expand the current understanding of NAD+ metabolism, with the discovery of trigonelin as a new precursor to NAD+. This research raises the possibility of creating interventions using NAD+-producing vitamins for longevity and age-related disease management. said one of the researchers, Associate Professor Vincenzo Sorrentino from the Healthy Longevity Translational Research Program at the National University of Singapore.

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