February 1, 2023

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Does Jane age?  The scientists' new discovery may surprise you

Does Jane age? The scientists’ new discovery may surprise you

get old It is an indispensable component of human life. The genes of age have remained elusive until now despite many attempts to uncover them. However, researchers from Northwestern University discovered this during the analysis As we age, there is an increasing imbalance of genes In almost every cell of the body, be it mice or humans. So this might suggest that There are no specific, specific genes that control the aging process.

Aging can be regulated by changes at the level of gene structure, which can affect thousands of different genes and related proteins simultaneously. The researchers note that changes to a single gene are so small that they don’t matter, and here’s why So far they have not been able to register them.

‘We focused primarily on a small number of genes, thinking that some genes would solve the problem,’ said Dr. Luis Amaral of Northwestern University. So maybe we weren’t focused on the right things before. Now that we have this new understanding, it’s like we have it new tool. It’s like Galileo with a telescope looking into space. It will allow us to look at gene activity through this new lens View biological phenomena differently.

The human genome consists of Gotwhich contains the appropriate instructions needed for the construction and functioning of cells. They are defined as “base pairs” of four chemicals. For these instructions to “take effect”, the DNA must be “read” and then transcribed (transcribed) into RNA. Genetic readouts are called Copy.

It is a kind of “mobile library of genetic recipes”, that is, the cell works thanks to it. The content of this library seems to change with age. It occurs in young people Balance of long and short textsHowever, as we age, some genes become more dominant. It has been observed that the shorter clones reproduce with age.

changes in gene activity It’s very, very small, and these small changes involve thousands of genes. We found that this change was consistent across tissues and across animals. We found it almost everywhere. I find it very important that one relatively brief principle appears to explain almost all of the changes in gene activity that occur in animals with age, says Dr. Thomas Stoeger of Northwestern University.

The research team first studied the transcriptomes of the animals and noted, for example, that four-month-old rats were relatively young The longest averages long textsfrom 9-month-old mice. On the other hand In humans, transcriptome length has been found to be a predictor of age.

The older research group (50 to 69 years old) compared to the younger group (30 to 49 years old) had Longer clones that were less likely to ‘match’ or become functionally active with shorter clones. It should be noted that this happened regardless of gender. The researchers say that aging cannot be reduced to a single source, which is an imbalance of transcription. They say that “many environmental and internal conditions” can lead to increased activity of short transcripts in the body.

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