Corona Virus. One vaccine may protect against different variants of SARS-CoV-2

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Scientists from Northwestern University have shown that vaccination and infection with the Corona virus may provide broader immunity against the like Corona Virus.

One vaccine will protect against different types of coronavirus. Cross resistance is possible

Until our study, it was not clear if anyone exposed to one coronavirus would be able to acquire immunity to others. We have shown that this is the case – says the professor. Pablo Penaloza-MacMaster, author of a work published in the Journal of Clinical Investigation.

The researchers explained that there are three main groups of coronaviruses. One of them together is SARS-CoV-2 and SARS-CoV-1 (which causes SARS).

The second group includes, among others, the virus that causes respiratory syndrome in the Middle East, and the third virus that causes the common cold.

Scientists have shown that the plasma of people vaccinated against SARS-CoV-2 contains antibodies that are also active against SARS-CoV-1, as well as virus Colds OC-43. At the same time, mice vaccinated against SARS-CoV-1 were resistant to SARS-CoV-2.

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It has also been shown that infection with one virus can protect against infection infection the following. However, it is important that the viruses are related to each other. Vaccination of mice against SARS-CoV-2 offered some but only limited protection against the common cold virus OC-43. The reason is that SARS-CoV-2 – SARS-CoV-1 are closely related and OC-43 is completely different from them.

As long as the similarity between the coronavirus was greater than 70%, the mice were protected. If they are exposed to a virus from a completely different group, vaccination is less effective, says the professor. Penalosis-MacMaster.

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This means that there will not be a universal vaccine against all coronaviruses. However, it is theoretically possible to develop preparations that protect against certain groups of pathogens, such as SARS-CoV-2-associated or causative viruses. Colds.

The scientists were urged to carry out the described study from their many years of experience developing a vaccine against the mutant virus human immunodeficiency virus.

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“The reason we don’t get immunized against HIV is because it’s hard to get reactive antibodies. So we thought, what if we tackle the problem of coronavirus diversity, which is very important wash A universal vaccine, the same way we approached developing an HIV vaccine? Professor reports. Penalosis-MacMaster.

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