Rogue agent Jason Bourne (Matt Damon) is still being hunted by the very people at the CIA that transformed him into a killer. Still suffering from amnesia and determined to finally learn of his true identity, he is lured out of hiding to make contact with a journalist named Simon Ross (Paddy Considine), who has been following his story. Throughout his research, Ross has gathered up valuable information about Bourne and Treadstone, the organization that trained him. That’s rather inconvenient for US government offical Noah Vosen (David Strathairn), who is looking to start up a new organization under the codename Blackbriar that would follow in Treadstone’s footsteps.

With intent to kill Bourne and the journalist before they expose the program’s disturbing secrets, Vosen sends agent Pam Landy (Joan Allen) to lead the search effort. Simultaneously, Paz (Edgar Ramirez), one of the remaining few living Treadstone assassins, is dispatched to take both Bourne and Ross out. In order to finally learn of his true origins and find some inner peace, Bourne will have to evade, outsmart, and outmaneuver the deadliest group of highly-trained killers yet.