This is the follow up to the horror film, House of 1000 Corpses, which was finally released in April, 2003 by Lions Gate Films after being kept on a shelf for quite some time by Universal Pictures, the film's original distributor. In sharp contrast, Lions Gate is looking to produce and release this movie within a year of the first film's release.

The original film started with a limited release, and ended up making $12.5 million in the U.S. Lions Gate is going to try a wide release right away this time, referring to the first film's $7,700+ per-screen-average for its first week, which if duplicated with a wide release of say, 2,500 theaters, could result in a weekend gross in the $20 million range. Lions Gate is hoping this second film will be successful enough for the "House of 1,000 Corpses" series to keep going with further sequels.

The unthinkable horror and chaos continues a few weeks after the events depicted in House of 1000 Corpses, as this film's focus shifts to a conflict between the various evil family members of the first movie and a new set of murderous loonies, in a blood-soaked road movie that leaves that 'House' with all its corpses. With two gangs of bloodthirsty bodily mutilation enthusiasts set loose at each other's necks, who will emerge victorious? The conflict starts when the 'house of 1000 corpses' is raided by a S.W.A.T. team, where the events of the first film are discovered in all of their shocking horror... As the maniacs the media dubs "The Devil's Rejects" flee the scene of the many, many crimes as their house burns down, they take off on a bloody road trip...